Posterior Cortical Atrophy Is a Form of Young-Onset Alzheimer’s
Among 1,092 people with PCA, symptoms started around age 60, and 94 percent had amyloid plaques or neurofibrillary tangles.
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Among 1,092 people with PCA, symptoms started around age 60, and 94 percent had amyloid plaques or neurofibrillary tangles.
With several thousand people across the U.S. on the drug, wait times are long, and clinics are hiring. How to meet growing demand?
In mice, these Aβ fibrils avoid riling microglia and astrocytes. They also evade both PiB and lecanemab.
Using different methods and studying different populations, two studies report similar trajectories of fluid and imaging biomarkers over a 20-year span of AD.
Modeling physiological dipeptide repeat expression and partial loss of normal C9ORF72 protein, new knock-in mice show a TGF-β1-driven collagen response in their spinal neurons.
Cerebrospinal fluid rides the pulses of cerebral arteries to enter the brain and spread into cortical tissue. This supports the existence of a human glymphatic system.
In peripheral macrophages and microglia, the receptor disrupts glucose metabolism. TREM1-deficient amyloidosis mice also had healthier neurons, better memories.
The company announced it would halt its post-market trial and stop selling the drug; the rights to it now revert to Swiss company Neurimmune.
Axons touch arterioles, releasing glutamate that makes smooth muscle cells relax. This increases cerebral blood flow in mice.
The biomarker may signal tau’s early days of entanglement, and serve as a useful disease staging indicator, according to a new immunoassay.
A U.K. Biobank analysis generated 15 risk factors for young-onset dementia. Many factors also correlated with late-onset disease.
Risk variant promotes TMEM106b fibrillization; protective variant discourages it.
A new, stem-cell-based method generated neural cultures that live long enough to suffer the consequences of TDP-43 dysregulation.
People receiving personalized Type 2 diabetes management were 28 percent less likely to develop dementia, and 15 percent less likely to get Alzheimer's.
A single-nuclei RNA-Seq study found more autophagy and chaperone gene expression in familial AD brain, more intense microglial activation in sporadic.